If you are upgrading to 2.5.0 RC 1 from previous versions, please make sure that you use the updated Application.cfc and index.cfm files in the Application Template folder. Application.cfc support has changed a lot of how the framework boots up and it has gotten more solid as the release approaches. However, changes have been made since the first beta of 2.5 and will solidify until the release. So if you are upgrading, please make sure you upgrade your Application.cfc and index.cfm file templates. 2.5 supports Application.cfm still, however, you must use the index.cfm template to include the /coldbox/system/coldbox.cfm file. AGAIN, PLEASE UPDATE YOUR SOFTWARE TO USE THE INCLUDED APPLICATION.CFC AND INDEX.CFM